It has overwhelmed hospitals within a few days, forced people to re-imagine their holiday celebrations and fueled a debate over school reopenings.
While the future of the pandemic in the US is still unclear, here's what has happened in the last few days.
The following day, Trump delivered a speech on the White House's South Lawn where few guests appeared to be practicing social distancing and many were not wearing masks.
Some Americans altered their traditional Fourth of July celebrations while others flocked to beaches to enjoy the holiday weekend.
Crowds were spotted in Myrtle Beach, South Carolina; New York's Coney Island and the California beaches of San Diego. In Miami and Los Angeles, beaches remained empty after officials kept them closed for the weekend.
The Covid-19 testing capacity has increased considerably since March but the recent surge of cases is causing long lines to get tested and slow results.
The number of daily hospitalizations in numerous states has been rising, putting critical resources including staffing, beds and ventilators in short supply.
The debate over how schools would reopen in the fall has intensified this week amid coronavirus concerns.
Teachers in some of Florida's largest school districts are pushing back and gathered to protest.
"We're very much going to put pressure on governors and everybody else to open the schools, to get them open," Trump said at a White House event on Tuesday.
The league's modified tournament in Orlando, Florida, is set to kick off Wednesday after more than a dozen people, including FC Dallas and Nashville SC players have tested positive for the virus.