"To think that you can ignore the biologic and get the economy back, it's not gonna happen," Fauci, the nation's leading infectious diseases expert, told actor Matthew McConaughey in an interview on Instagram.
"It's just not gonna happen. You gotta do both. You gotta get control of the biologic as you carefully open the country."
Fauci emphasized the importance of acting in a measured, prudent way. He noted that Americans have seen the consequences of jumping over the guideposts that have been established for safe reopening.
He said it goes beyond the financial aspects and that what happens it could be devastating psychologically and medically
"If you're really shut down, children may not get their vaccinations. People don't go to hospitals when they get chest pain," he added. "There's a lot of different things that could go wrong, beyond the economy."
He also gave another grim warning. "There's projections that if you stay shut down, the number of deaths unrelated to Covid will go up," he said. "The number of suicides, overdoses, family issues, such as child abuse and things like that, they all go up."
Ultimately, Fauci said that he believes the country can come together to overcome the virus.
"For your country right now and for the war that we're in against Covid, I'm asking you to do four simple things: wear a mask, social distance, wash your hands and be smart about crowds," said Dr. Robert Redfield, director of the US Centers for Disease Control and Prevention.
"I'm not asking some of America to do it," he told WebMD. "We all gotta do it."
Without following the recommendations, this could be "the worst fall, from a public health perspective, we've ever had," he said.
Some officials are already preparing for the coming months.
"It is now obvious to everyone that Covid-19 is not going away over the next five months," Kansas City Health Department Director Dr. Rex Archer said in a news release Thursday. "As we move out of summer and into fall and winter, we will still be confronting this health emergency."
The flu season also occurs in the fall and winter, the CDC said.
Coronavirus continues to spread at high rates across the South, Midwest and West -- even as the total number of new cases has declined following a summer surge.
The seven-day average of daily coronavirus deaths was over 1,000 on Thursday, the 18th consecutive day the US averaged over 1,000 deaths per day.
"You can't run away from the numbers," Dr. Anthony Fauci, director of the National Institute of Allergies and Diseases, said during a National Geographic panel Thursday. "You can't run away from the numbers of people who've died, the number of people getting hospitalized, the surges we're seeing."
As educators and parents clash over starting in-person classes, some schools that have reopened have seen new cases.
In Georgia, more than 1,100 students, teachers and staff in the Cherokee County School District. about 40 miles north of downtown Atlanta, are under quarantine due to dozens of Covid-19 positive cases or exposure. Schools reopened 10 days ago.
"The children in this beautiful state are not disposable, but that is exactly how you and the superintendent are regarding them," Brandy Heath, a mother of two Cherokee County students, wrote in a letter to Georgia Gov. Brian Kemp.
In Florida, a day after the Martin County School District reopened for in-person teaching, an entire elementary class and one bus route were placed under quarantine after a student showed coronavirus symptoms, spokeswoman Jennifer DeShazo said Wednesday.
In new guidance released Thursday, the American Academy of Pediatrics (AAP) advised face coverings can be worn safely by children over the age of 2, except for rare exceptions.
An ensemble forecast published by the CDC projects the total number of deaths from coronavirus will reach nearly 189,000 in the next three weeks.
The new projections, published Thursday, forecast 188,982 deaths by September 5, with a possible range of 181,375 to 201,431 deaths.
"State- and territory-level ensemble forecasts predict that the number of reported new deaths per week may increase over the next four weeks in Colorado and may decrease in Arizona, the Northern Mariana Islands, Vermont, and Wyoming," the CDC says on its forecasting website.
The prediction relies on about two dozen individual forecasts from outside institutions and researchers.
Unlike some individual models, the CDC's ensemble forecast offers projections only about a month ahead. A previous ensemble forecast, published July 23, projected roughly 164,477 coronavirus deaths by Saturday.
At least 167,029 people have already died from Covid-19 in the United States, according to data compiled by Johns Hopkins University.
The CDC's Dr. Redfield is cautiously optimistic that one or more coronavirus vaccines will be ready by the start of 2021. There are 270 active trials for coronavirus treatments, experts say.
Director of the National Institutes of Health Dr. Francis Collins expects the National Academy of Sciences to make "interim, high-level" recommendations about who should get priority for a vaccine by Labor Day.
"That would probably include such people as the elderly, residents of nursing homes, health care providers, other people at high risk for chronic illnesses," Collins said Thursday.
But anti-vaxxers have taken to social media to spread lies about the future coronavirus vaccine. Some include claims it contains monkey brains or that it's a CIA plot to take over the world. Others allege the vaccine will include an invisible trackable tattoo or it will disfigure those who take it.
As the lies spread, the government's multi-billion-dollar vaccine effort has yet to come up with a public education campaign to counteract disinformation.
The stakes are high. A third of Americans said they'd not get vaccinated against coronavirus, even if the vaccine is widely available and low cost, according to a CNN poll in May.
"Speaking for myself, I think I underestimated the level of public resistance," Collins told CNN. "I didn't expect it to be that widespread."
Dr. Tina Hartert of the Vanderbilt University Medical Center said lack of faith in the vaccine can lead to major outbreaks. She described the government's communication on the vaccine as crucial.
"We should have started on this months ago but it's never too late to start this important messaging. Because otherwise the messaging people will listen to is the story of one child from another parent," Hartert told CNN's Anderson Cooper.
Dr. Mike Ryan, the executive director of the World Health Organization's Health Emergencies Programme, said governments will need to have a "dialogue" with their citizens about vaccination.
"I think science and government have a job to do that is to make the case," Ryan said Thursday. "I think communities and people have a job to do, which is to listen to that case, and hopefully the result of that will be a widely accepted successful vaccine that could bring this pandemic to an end."
CNN's Joe Sutton, Rosa Flores and Sara Weisfeldt contributed to this report.