Arsenal will host Manchester United in the standout fixture of the FA Cup fourth round following Monday's draw.
The match at the Emirates Stadium will see the two most successful sides in the competition go head-to-head, as Gunners boss Unai Emery and United manager Ole Gunnar Solskjaer seek to secure silverware in their debut campaigns as manager.
Elsewhere there's a London derby between Crystal Palace and Tottenham Hotspur to look forward to at Selhurst Park. Holders Chelsea will meet either Luton Town or Sheffield Wednesday, while Manchester City host Burnley at the Etihad Stadium.
Here is the draw in full for Round 4 of the competition:
Swansea City vs. Gillingham
AFC Wimbledon vs. West Ham United
Shrewsbury Town vs. Wolverhampton Wanderers
Millwall vs. Everton
Brighton & Hove Albion vs. West Bromwich Albion
Bristol City vs. Bolton Wanderers
Accrington Stanley vs. Derby County or Southampton
Doncaster Rovers vs. Oldham Athletic
Chelsea vs. Sheffield Wednesday or Luton Town
Newcastle United or Blackburn Rovers vs. Watford
Middlesbrough vs. Newport County
Manchester City vs. Burnley
Barnet vs. Brentford
Portsmouth vs. Queens Park Rangers
Arsenal vs. Manchester United
Crystal Palace vs. Tottenham Hotspur
Matches will be played between Friday, January 25 and Monday, January 28.
Arsenal and United to Renew FA Cup Rivalry
After safely making it into the fourth round of the competition with wins over lower league opponents at home, Arsenal and United will face a much tougher assignment in their next FA Cup fixture.
It's a match that will stir memories of thrilling clashes gone by between these two sides, most notably the famous win for United in the 1999 semi-final and Ryan Giggs' iconic goal that seized victory for the Red Devils at Villa Park.
Overall, there aren't any sides capable of matching the pedigree of these two when it comes to the FA Cup:
Aside from that incredible game almost 20 years ago, the Gunners tend to get the better of the Red Devils in this competition too:
These two sides aren't to the standard they were in 1999, and with neither side currently in a strong position to qualify for the UEFA Champions League this term, this cup competition is likely to take on extra significance.
The same is true for Tottenham. While they remain in the hunt for four prizes at the start of 2019, they have yet to win silverware under manager Mauricio Pochettino; a trophy of any sort would be the cap on the excellent progress they have made in recent years.
A trip to Palace is far from ideal for them though. Spurs won this fixture 1-0 earlier in the season in the Premier League, but Roy Hodgson's team have found some form as of late and with a midtable finish likely, they will surely throw everything at this competition.
HLTCO thinks there are good omens for the Eagles:
Elsewhere, Chelsea will be confident of progressing with another draw at home against a lower league outfit. City will also be the big favourites when they meet Burnley, who are struggling in the Premier League this term.
Barnet, the only non-league team left in the competition, will host Brentford. After upsetting Leicester City on Sunday, Newport County's reward is a trip to Middlesbrough.