"Cherry's always trying to get me to go out more and more," Sheeran said. "She [Cherry] thinks it’s not healthy to do this [stay in all the time]...
"I lost the ability to go to a supermarket and buy a loaf of bread about three years ago.
"It makes me feel like I’m not human. If you want to come up to me and have a conversation with me. Even if we’ve never met, just come up. But what instantly cuts me off is that you’re having a moment with them which is so genuine and so nice and then at the end they ask for a picture.
"It puts you down to earth and you’re just 15 likes on Instagram. That’s all you are."
Watch: Ed Sheeran performs "Drunk in Love" with Beyonce. Post continues after video.
Sheeran recounted a time a man showed an act of kindness, by not asking him for a photo, which has stuck with him since.
"I was at a Marilyn Manson show and this guy shook my hand and said he liked my music, and that was it. That was so nice and it meant so much. Like if I am eating in a restaurant now, I would prefer to have a private room because if I eat in the public room I have people filming me while I’m eating my food. You feel like a zoo animal. I don’t mean to be complain-y, I have a cool job and life. But if I can avoid it I will."
He's not the first celebrity to be open about how fame has brought their struggle with anxiety to dizzying new heights.
Justin Bieber, who collaborates with Sheeran in his new album No. 6 Collaborations Project, shared with his Instagram followers earlier this year that he is "going through it".
"Fight for what you love and who you love don’t let fear and anxiety win," he wrote. "God has not given us a spirit of fear but of power love and of a sound mind!"
"I haven't (sic) believed the truth about myself I haven’t believed I am loved I haven’t believed I am forgiven it’s a hard thing for me to wrap my head around," he shared. "I hang my head in shame and I wallow in sadness about the the people who have betrayed me."
Both celebrities have spoken about needing to reduce their inner circle to lessen their anxiety.
Watch the full interview with Ed Sheeran.
If you are struggling with anxiety, support is available via Beyond Blue. Call 1300 22 46 36.