The Bears-Raiders matchup will be the first of four regular-season games played in London this season, including two at the newly constructed home of English Premier League power Tottenham Hotspur.
The other two London games will be played at Wembley Stadium. The first will be on Oct. 27 between the reigning NFC champion Los Angeles Rams and the Cincinnati Bengals, followed by an AFC South showdown between the Jacksonville Jaguars and Houston Texans on Nov. 3.
The Green Bay Packers are the only NFL team that has yet to play in the U.K.
It will be the first game in Mexico City for both teams.
Last November, the NFL moved the Chiefs' game against the Rams from Mexico City to the Los Angeles Memorial Coliseum because of poor field conditions at Estadio Azteca.
The NFL will release the rest of its 2019 schedule on Wednesday night.